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Centromere Location and Chromosome Separation

A centromere is a region on a chromosome that joins sister chromatids. Sister chromatids are double-stranded, replicated chromosomes that form during cell division. The primary function of the centromere is to serve as a place of attachment for spindle fibers  during cell division. The spindle apparatus elongates cells and separates chromosomes  to ensure that each new daughter cell has the correct number of chromosomes at the completion of mitosis and meiosis. The DNA in the centromere region of a chromosome is composed of tightly packed chromatin known as heterochromatin. Heterochromatin is very condensed and is therefore not transcribed. Due to its heterochromatin composition, the centromere region stains more darkly with dyes than the other regions of a chromosome. Key Takeaways Centromeres are regions on a chromosome that join sister chromatids whose primary function is for the attachment of spindle fibers in cell division.While centromeres are typically located in the central area of a chromosome, they can also be located near the mid-region or at a number of different positions on the chromosome.Specialized zones on centromeres called kinetochores attach the chromosomes to spindle fibers in prophase in mitosis.Kinetochores have protein complexes that generate kinetochore fibers. These fibers help to orient and separate chromosomes during cell division.In meiosis, in metaphase I, the centromeres of homologous chromosomes are oriented toward opposite cell poles while in meiosis II, spindle fibers extending from both cell poles attach to sister chromatids at their centromeres. Centromere Location A centromere is not always located in the central area of a chromosome. A chromosome is comprised of a short arm region (p arm) and a long arm region (q arm) that are connected by a centromere region. Centromeres may be located near the mid-region of a chromosome or at a number of positions along the chromosome. ​ Metacentric centromeres are located near the chromosome center.Submetacentric centromeres are non-centrally located so that one arm is longer than the other.Acrocentric centromeres are located near the end of a chromosome.Telocentric centromeres are found at the end or telomere region of a chromosome. The position of the centromere is readily observable in a human karyotype of homologous chromosomes. Chromosome 1 is an example of a metacentric centromere, chromosome 5 is an example of a submetacentric centromere, and chromosome 13 is an example of an acrocentric centromere. Chromosome Segregation in Mitosis Prior to the start of mitosis, the cell enters a stage known as interphase where it replicates its DNA in preparation for cell division. Sister chromatids are formed that are joined at their centromeres.In prophase of mitosis, specialized regions on centromeres called kinetochores attach chromosomes to spindle polar fibers. Kinetochores are composed of a number of protein complexes that generate kinetochore fibers, which attach to spindle fibers. These fibers help to manipulate and separate chromosomes during cell division.During metaphase, chromosomes are held at the metaphase plate by the equal forces of the polar fibers pushing on the centromeres.During anaphase, paired centromeres in each distinct chromosome begin to move apart as daughter chromosomes are pulled centromere first toward opposite ends of the cell.During telophase, newly formed nuclei enclose separated daughter chromosomes. After cytokinesis (division of the cytoplasm), two distinct daughter cells are formed. Chromosome Segregation in Meiosis In meiosis, a cell goes through two stages of the dividing process. These stages are meiosis I and meiosis II. During metaphase I, the centromeres of homologous chromosomes are oriented toward opposite cell poles. This means that homologous chromosomes will attach at their centromere regions to spindle fibers extending from only one of the two cell poles.When spindle fibers shorten during anaphase I, homologous chromosomes are pulled toward opposite cell poles but sister chromatids remain together.In meiosis II, spindle fibers extending from both cell poles attach to sister chromatids at their centromeres. Sister chromatids are separated in anaphase II when spindle fibers pull them toward opposite poles. Meiosis results in the division, separation, and distribution of chromosomes among four new daughter cells. Each cell is haploid, containing only half the number of chromosomes as the original cell. Centromere Anomalies Centromeres play an important role by participating in the separation process for chromosomes. Their structure however, can make them possible sites for chromosome rearrangements. Keeping the integrity of centromeres intact is thus an important job for the cell. Centromere anomalies have been linked to various diseases like cancer.

Unit 5 Biology - 1810 Words

39) Name the specific type of plant tissue or cell that performs the following functions: a) waterproofing the surface layer Endodermos b) rapidly dividing into new cells Mitosis c) transporting sugars throughout the plant Phloem 40)Maple syrup is produces from the sap moving in the xylem of maple trees in the early spring. How would taking too much sap in the spring harm the maple tree? That sap is an energy store to give it a strong start in spring. If you take too much, that is less energy for the tree to use. 41) A number of plants are currently being stydies for use in cleaning up land sites contanining toxic substances. a)name the technique of using plants for this purpose Phytoremediation†¦show more content†¦b)self-pollination Would always result in the same type of plant, but higher chance of survival because it can reproduce by itself rather than having to have other plants around. 50) 51) A botanist wanted to see if a new strain of corn could germinate in soil that was too salty for regular corn. She conducted a study on the germination success of seeds from the new strain that were exposed to various levels of salty soil, from zero to normal (100mg/L) to high (200 mg/L) to very high (400 mg/L) to normally lethal (800 mg/L) a) Write a formal hypothesis for this study. b) Does her data support or reject the hypothesis? Explain. If the answer is love then corn definitely doesnt love normally lethal concentrations :). On a more serious note: Lets say a valid hypothesis will be: The new strain of corn is able to germinate successfully and tolerate salt concentrations which are normally lethal for regular corn plants. Now, in order to actually measure this hypothesis, you would need results for salt tolerance of regular corn as well because only with these results you dont have anything to compare it against. However, if we assume that as it say concentrations of 800 mg/l are normallyShow MoreRelatedNat Books Essay1170 Words   |  5 PagesScience: NCERT Class VI †¢ Science: NCERT Class VII †¢ Science: NCERT Class VIII †¢ Science: NCERT Class IX †¢ Science: NCERT Class X †¢ Science: NCERT Class XI – Chemistry: Unit 14 Biology: Units 4 5 †¢ Science: NCERT Class XII – Chemistry: Unit 16 Biology: Units 8, 9 10 NCERT Books: Environment Ecology †¢ Science: Class XII – Biology: last four Chapters (13 to 16) NCERT Books List for UPSC Preparation/Must read NCERT books for UPSC/NCERT books for UPSC list Class Textbooks 6th History: Our PastRead MoreA Study On The Community Health Course1187 Words   |  5 Pages The Community health Course was the longest course and was taught over the 5 year period in different modules that carried different credit units and different contact hours. The course was divided into 8 modules with a total of 14 credit Units. 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McMath has a population of 1200 students in grades 8 to 12 who are from diverse backgrounds such as Korea, India, China, Brazil, Europe, and Japan.Read MorePh Lab Report1683 Words   |  7 PagesThe different methods of measuring acids and bases in a solution By Starsky Intro to Biology September 26, 2011 Lab Partners: Kristen, Tania and Betty Introduction When using different methods to measure pH levels there are some tools that can be useful. 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